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LNP delivery system excipient mPEG-DSPE-2K

140.00 USD ($)/Gram

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Product Details:

Storage Freezer
Melting Point 53 ~ 54
Taste Other
Molecular Formula C45H87NNaO11P
Smell No Smell
HS Code 3907209090
Solubility Sparingly soluble in Chloroform and Methanol
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Product Description

LNP delivery system excipient mPEG-DSPE-2K Price And Quantity

Minimum Order Quantity 1 Gram
Price 140.00 USD ($)/Gram

LNP delivery system excipient mPEG-DSPE-2K Product Specifications

Purity(%) Not less than 95.0%
Molecular Formula C45H87NNaO11P
Chemical Name 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
Appearance White or off-white solid
Taste Other
Melting Point 53 ~ 54
Storage Freezer
Type Other
Shelf Life 24 Months
Solubility Sparingly soluble in Chloroform and Methanol
Medicine Name 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
Physical Form Powder
Grade Medicine Grade
CAS No 147867-65-0
Usage DSPE-MPEG2000 is used as one of the LNP Delivery System Excipients for mRNA medicines or drugs.
HS Code 3907209090
Smell No Smell

LNP delivery system excipient mPEG-DSPE-2K Trade Information

FOB Port Shanghai or Beijing
Supply Ability 10000 Gram Per Month
Delivery Time 10 Days
Sample Available Yes
Sample Policy If order is confirmed we will reimburse the sample cost
Packaging Details 1g/bottle, 5g/bottle or according to the requirements from customers.
Main Export Market(s) Asia Australia North America Western Europe Middle East Africa Eastern Europe South America Central America
Main Domestic Market All India
Certifications ISO

Product Description

MPEG2000-DSPE combines the amphiphilic properties of phospholipids and the hydrophilic polymer properties of PEG. In recent years, its application in drug carriers such as long-circulating liposomes, polymer micelles, and long-circulating nanoparticles has achieved rapid development. According to the management of pharmaceutical excipients in my country, the molecular weight of polyethylene glycol in the MPEG2000-DSPE molecule is about 2000, which is suitable for the preparation of long-circulating liposomes, so that liposomes will not be captured by MPS-rich tissues immediately after intravenous injection. As a result, the circulation time in the blood is prolonged, thereby increasing the chance of entering pathological tissues.

The amount of MPEG2000-DSPE in doxorubicin liposome DOXIL accounted for 20% of the total lipid, and compared with ordinary doxorubicin liposome Mycoet, the kinetic difference was obvious. The plasma half-life of liposomal doxorubicin, DOXIL is 2.5d, while Myocet is only 0.07h.

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DALIAN HANDOM CHEMICALS CO.,LTD.

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